| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6129416 | Clinical Microbiology and Infection | 2015 | 5 Pages |
Abstract
To investigate the global occurrence of trimethoprim-sulfamethoxazole resistance and the genetic mechanisms of trimethoprim resistance, we analysed Staphylococcus aureus from travel-associated skin and soft-tissue infections treated at 13 travel clinics in Europe. Thirty-eight per cent (75/196) were trimethoprim-resistant and 21% (41/196) were resistant to trimethoprim-sulfamethoxazole. Among methicillin-resistant S. aureus, these proportions were 30% (7/23) and 17% (4/23), respectively. DfrG explained 92% (69/75) of all trimethoprim resistance in S. aureus. Travel to South Asia was associated with the highest risk of acquiring trimethoprim-sulfamethoxazole-resistant S. aureus. We conclude that globally dfrG is the predominant determinant of trimethoprim resistance in human S. aureus infection.
Keywords
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Authors
D. Nurjadi, J. Schäfer, B. Friedrich-Jänicke, A. Mueller, A. Neumayr, A. Calvo-Cano, A. Goorhuis, N. Molhoek, H. Lagler, A. Kantele, P.J.J. Van Genderen, J. Gascon, M.P. Grobusch, E. Caumes, C. Hatz, R. Fleck, F.P. Mockenhaupt, P. Zanger,