| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6129506 | Clinical Microbiology and Infection | 2015 | 4 Pages |
Abstract
We performed a retrospective cohort study of hospitalised cryptococcal meningitis (CM) patients at a single centre to evaluate the clinical epidemiological features of paradoxical cryptococcal-related immune reconstitution inflammatory syndrome (CM-IRIS) in a setting in China. A total of 154 AIDS patients with CM were involved, and 17.5% experienced IRIS at a median of 27 days after initiation of antiretroviral therapy (ART). Overall, 3 deaths were directly attributed to IRIS. The occurrences of CM-IRIS were independently associated with the pre-ART CD4Â +Â count, pre-C-reactive protein level, and the timing of ART initiation.
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Authors
S. Yan, L. Chen, W. Wu, Z. Li, Z. Fu, H. Zhang, J. Xue, Y. Hu, J. Mou, C. Fu,