Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6129699 | Clinical Microbiology and Infection | 2015 | 5 Pages |
Abstract
In order to investigate the association between length variation of the CD209L neck region and human immunodeficiency virus (HIV)-1 susceptibility, disease progression, and treatment response outcomes, we genotyped 139 HIV-1-seropositive and 109 seronegative individuals. The heterozygous genotype 6/5 showed a significant increased risk of HIV-1 infection (OR 3.03, 95% CI 0.99-9.33, p 0.046). Moreover, after highly active antiretroviral therapy (HAART), HIV-1-seropositive individuals carrying the 6/5, 7/5 and 7/7 genotypes and alleles 5, 6 and 7 showed good CD4+ T-cell recovery. In addition, individuals with the 7/5, 6/6 and 7/7 genotypes showed a significant decrease in viral load during the treatment period as compared with baseline (p < 0.05). Interestingly, we found that alleles 4 and 6 were associated with protection against AIDS progression. D209L variation may influence susceptibility to HIV-1, response to treatment, and disease progression.
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Authors
N. Fayssel, R. Bensghir, A. Ouladlahsen, H. Abdelghaffar, M. Sodqi, K. Lahlou, S. Benjelloun, K. Marhoum El Filali, S. Ezzikouri, L. Wakrim,