| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6130672 | Clinical Microbiology and Infection | 2013 | 4 Pages |
Abstract
The aim of this work was to assess the value of the physical status of human papillomavirus (HPV) DNA as a disease marker for cervical cancer development in a set of 248 DNA samples previously genotyped as HPV 16 or 18, by calculating the E2/E6 ratio through real-time PCR. There was a significant difference in integration status according to disease grade for both genotypes (p <0.001). Furthermore, especially for HPV 18, determining the DNA physical status could be a useful biomarker in predicting cervical cancer risk development, with a lower E2/E6 ratio clinically associated with the development of a precancerous lesion.
Related Topics
Life Sciences
Immunology and Microbiology
Microbiology
Authors
A. GradÃssimo Oliveira, C. Delgado, N. Verdasca, Ã. Pista,