Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6131121 | Clinical Microbiology and Infection | 2012 | 4 Pages |
Abstract
The emergence of carbapenem resistance in Pseudomonas aeruginosa threatens the efficacy of this important anti-pseudomonal antibiotic class. Between 2003 and 2006, an increase in the number of carbapenem-resistant P. aeruginosa isolates at the Zonguldak Karaelmas University Hospital was observed (Zongul-dak, Turkey). To assess the imipenem resistance mechanisms emerging in these P. aeruginosa isolates, they were characterized by amplified fragment length polymorphism typing, which revealed diversity among imipenem-resistant isolates as well as two clonally related outbreak groups. The molecular mechanism of carbapenem resistance was characterized in a representative isolate from each clonal group. Mutational disruption of oprD was the most frequently encountered resistance mechanism (23/27 isolates).
Keywords
Related Topics
Life Sciences
Immunology and Microbiology
Microbiology
Authors
M. Mac Aogáin, C. Kulah, M. Rijnsburger, G. Celebi, P.H.M. Savelkoul, F. O'Gara, M.J. Mooij,