| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6131490 | Current Opinion in Microbiology | 2016 | 5 Pages |
Abstract
The oxadiazoles are a class of antibacterials discovered by in silico docking and scoring of compounds against the X-ray structure of a penicillin-binding protein. These antibacterials exhibit activity against Gram-positive bacteria, including against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE). They show in vivo efficacy in murine models of peritonitis/sepsis and neutropenic thigh MRSA infection. They are bactericidal and orally bioavailable. The oxadiazoles show promise in treatment of MRSA infection.
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Authors
Jeshina Janardhanan, Mayland Chang, Shahriar Mobashery,