Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6131615 | Current Opinion in Microbiology | 2016 | 5 Pages |
Abstract
Homeostatic interactions between helminths, commensals and the host immune system; red arrows denote pro-inflammatory pathways, blue arrow counter-inflammatory. Direct tissue damage provokes release of alarmins (IL-33, also TSLP and IL-25) and can allow bacterial translocation with consequent TLR stimulation of host cells. Helminth secreted products (ES) are known to inhibit expression of the IL-33R (ST2) and host responses to TLR ligation. In addition, both helminths and commensals maintain host immunoregulatory networks through ES products and the production of short chain fatty acids (SCFAs).167
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Authors
William C Gause, Rick M Maizels,