| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6132063 | Current Opinion in Microbiology | 2013 | 7 Pages |
Abstract
⺠Two-component signaling pathways are highly specific, exhibiting minimal cross-talk. ⺠Specificity stems from molecular recognition, phosphatases, and substrate competition. ⺠Specificity residues coevolve following a duplication to insulate the new pathways. ⺠Avoiding cross-talk is a major selective pressure acting on two-component proteins. ⺠Tethering a kinase to a substrate relaxes pressure to diversify specificity residues.
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Authors
Anna I Podgornaia, Michael T Laub,