| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6132184 | Current Opinion in Microbiology | 2014 | 8 Pages |
Abstract
Type IV secretion (T4S) systems are large dynamic nanomachines that transport DNAs and/or proteins through the membranes of bacteria. Because of their complexity and multi-protein organisation, T4S systems have been extremely challenging to study structurally. However in the past five years significant milestones have been achieved by X-ray crystallography and cryo-electron microscopy. This review describes some of the more recent advances: the structures of some of the protein components of the T4S systems and the complete core complex structure that was determined using electron microscopy.
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Authors
Gabriel Waksman, Elena V Orlova,