| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6132281 | Current Opinion in Microbiology | 2009 | 6 Pages |
Abstract
Here we review the Bordetella virulence secretome with an emphasis on factors that translocate into target cells. Recent advances in understanding the functions of adenylate cyclase toxin, a type 1 secretion system (T1SS) substrate, and pertussis toxin, a type IV secretion system (T4SS) substrate, are briefly described and a compilation of additional secretion systems and secreted factors is provided. Particular attention is devoted to the Bsc type III secretion system (T3SS) and controversies surrounding it. Efforts to identify effector proteins, characterize in vitro and in vivo phenotypes, and the potential role of type III secretion during human infections are discussed.
Related Topics
Life Sciences
Immunology and Microbiology
Microbiology
Authors
Ruchi Shrivastava, Jeff F Miller,