Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6132292 | Current Opinion in Microbiology | 2012 | 6 Pages |
Abstract
⺠The genetics of strong selections may be a misleading basis for understanding antibiotic resistance evolution in clinical settings. ⺠Antibiotic-resistance evolution at non-lethal concentrations of drug is likely to select high-frequency low-cost genetic alterations. ⺠High-resolution competition assays show that resistance mutations are enriched, and selected de novo, at very low antibiotic concentrations. ⺠Genomic analysis of resistant clinical isolates needs to be complemented with experimental evolution studies and genetic reconstructions. ⺠It is important to determine the functional significance of each individual mutation in the trajectory of resistance evolution.
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Authors
Diarmaid Hughes, Dan I Andersson,