Article ID Journal Published Year Pages File Type
6132426 Current Opinion in Microbiology 2011 6 Pages PDF
Abstract

- Aspergillus fumigatus uses extracellular siderophores for uptake and intracellular siderophores for storage and trafficking of iron.
- Intracellular siderophore-mediated iron handling is important for germination, development, and antioxidative defense.
- Extra- and intracellular siderophores are crucial for virulence of A. fumigatus and a variety of other fungal species.
- The regulator HapX mediates adaptation to iron starvation by activating iron uptake and repressing iron consumption.
- HapX is crucial for virulence of A. fumigatus and a variety of other fungal species.
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