| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6132431 | Current Opinion in Microbiology | 2011 | 8 Pages |
Abstract
⺠Up to 18 IRG proteins defend mice against Toxoplasma gondii and two Chlamydia species, but not against several other organisms. ⺠IRG proteins disrupt the T. gondii parasitophorous vacuole. ⺠The IRG resistance system is absent from man, from several other mammals and from birds. ⺠Three specialised IRG family members (IRGM proteins) act as regulators of the activity of the others. ⺠IRG proteins in mice are inactivated by kinases secreted by virulent strains of T. gondii.
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Authors
Jonathan C Howard, Julia P Hunn, Tobias Steinfeldt,