| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6132443 | Current Opinion in Microbiology | 2011 | 7 Pages |
Abstract
⺠Transferrin receptor 1 (TfR1) is the cellular receptor for New World hemorrhagic fever arenaviruses. ⺠Commonalities between human TfR1 and TfR1 of arenaviral host species make zoonoses possible. ⺠TfR1 upregulation during the acute-phase response may amplify arenaviral replication. ⺠TfR1 may make a useful target for much needed therapies for arenaviral hemorrhagic fevers.
Related Topics
Life Sciences
Immunology and Microbiology
Microbiology
Authors
Hyeryun Choe, Stephanie Jemielity, Jonathan Abraham, Sheli R Radoshitzky, Michael Farzan,