Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6132469 | Current Opinion in Microbiology | 2011 | 7 Pages |
Abstract
RNA polymerases (RNAPs) make repeatedly use of their templates by cycling through initiation, elongation and termination phases of transcription; during each step RNAP is interacting with and regulated by distinct transcription factors. The dynamic interplay between nucleic acid sequences, transcription factors and RNAP affects the activity and distribution of transcription complexes across the genome, and ultimately executes the genetic programme of the organism. This review covers recent discoveries about the mechanisms of archaeal transcription obtained by a combination of in vivo and in vitro approaches, from the molecular to the global level.
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Authors
Dina Grohmann, Finn Werner,