Transcriptional profile of the intracellular pathogen Brucella melitensis following HeLa cells infection

► cDNA microarray revealed different pathogen expression profile at 4 and 12 h p.i. ► An adaptive-associated Brucella transcriptome was detected at 4 h p.i. ► Conversely, a replicate-associated transcriptional activity was observed at 12 h p.i. ► Molecular analysis correlates well with phenotypic studies.