Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6136423 | Microbial Pathogenesis | 2011 | 7 Pages |
Abstract
⺠We deleted the lef gene in the fully virulent Vollum strain. ⺠The mutation has no or little effect on the virulence in Guinea pigs. ⺠The mutation has limited effects on the virulence in rabbits. ⺠The mutant caused the death of 75%-50% of rabbits infected with spore doses higher than the WT LD50. ⺠The surviving rabbits were resistant to challenge with the wild type strain.
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Authors
Haim Levy, Shay Weiss, Zeev Altboum, Josef Schlomovitz, Nili Rothschild, Eran Blachinsky, David Kobiler,