Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6136450 | Microbial Pathogenesis | 2011 | 8 Pages |
Abstract
⺠Anisic aldehydes exert their antifungal activity by targeting plasma membrane H+ ATPase activity. ⺠Inhibition of H+ ATPase leads to intracellular acidification and cell death. ⺠Position of methoxy group attached to the benzene ring decides antifungal activity of the structure. ⺠SEM analysis showed severe breakage of the Candida cell. ⺠Test compounds may thus be taken as an alternate to a novel anticandidal drug.
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Authors
Sheikh Shreaz, Rimple Bhatia, Neelofar Khan, Sheikh Imran Ahmad, Sumathi Muralidhar, Seemi F. Basir, Nikhat Manzoor, Luqman A. Khan,