Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6196258 | Experimental Eye Research | 2016 | 4 Pages |
â¢Resident corneal myeloid derived cells recruit leukocytes early in adenovirus keratitis.â¢Adenovirus keratitis is diminished in dendritic and macrophage ablated MaFIA mice.â¢Both keratocytes and myeloid lineage cells in the corneal stroma play critical roles in the early innate immune responses to adenovirus corneal infection.
The cornea contains a heterogeneous population of antigen-presenting cells with the capacity to contribute to immune responses. Adenovirus keratitis is a severe corneal infection with acute and chronic phases. The role of resident corneal antigen-presenting cells in adenovirus keratitis has not been studied. We utilized transgenic MaFIA mice in which c-fms expressing macrophages and dendritic cells can be induced to undergo apoptosis, in a mouse model of adenovirus keratitis. Clinical keratitis and recruitment of myeloperoxidase and CD45+ cells were diminished in c-fms depleted, adenovirus infected mice, as compared to controls, consistent with a role for myeloid-lineage cells in adenovirus keratitis.