| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 621801 | Chemical Engineering Research and Design | 2012 | 8 Pages |
Abstract
⺠We loaded silica aerogel with nimesulide, a poorly water-soluble drug, using supercritical CO2 adsorption to form new kinds of drug delivery systems. ⺠We measured adsorption isotherms and adsorption kinetics and we described the curves by models. ⺠The sorption process was well described by a pseudo-second-order model. ⺠The drug/silica aerogel composites were characterized by different analytical techniques. ⺠The release rate of nimesulide from the composite, evaluated by in vitro dissolution tests, is much faster than that of the crystalline drug.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Filtration and Separation
Authors
Giuseppe Caputo, Mariarosa Scognamiglio, Iolanda De Marco,