Article ID Journal Published Year Pages File Type
621971 Chemical Engineering Research and Design 2007 7 Pages PDF
Abstract

As new field of application for sol-gel processes the cold and vacuum-free ‘compression’ of pharmaceutical tablets is proposed. Suspensions consisting of an active ingredient, a silica sol and an additive are consolidated by freezing and subsequent drying. Depending on the suspensions composition parameters like porosity and pore size, dissolution behaviour and crushing forces were investigated. Dendrite pore structures were formed as negative images of the former ice crystals in the tablet bodies. An increase of the binder ascorbic acid results in a decreasing porosity, a slower dissolution velocity but an increasing crushing force.

Related Topics
Physical Sciences and Engineering Chemical Engineering Filtration and Separation
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