Article ID Journal Published Year Pages File Type
6481650 Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 2016 9 Pages PDF
Abstract

•IAV infection activates transcription of antiviral genes.•NS1 protein of IAV binds cellular DNA.•NS1-dsDNA interaction prevents loading of transcriptional machinery.•Thus, NS1 suppresses IAV-mediated transcription of antiviral genes.

Influenza NS1 protein is an important virulence factor that is capable of binding double-stranded (ds) RNA and inhibiting dsRNA-mediated host innate immune responses. Here we show that NS1 can also bind cellular dsDNA. This interaction prevents loading of transcriptional machinery to the DNA, thereby attenuating IAV-mediated expression of antiviral genes. Thus, we identified a previously undescribed strategy, by which RNA virus inhibits cellular transcription to escape antiviral response and secure its replication.

Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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