| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6481905 | International Journal of Pharmaceutics | 2016 | 12 Pages |
Antimicrobial chitosan-polyethylene oxide (CS-PEO) nanofibrous mats containing ZnO nanoparticles (NPs) and hydrocortisone-imipenem/cilastatin-loaded ZnO NPs were produced by electrospinning technique. The FE-SEM images displayed that the spherical ZnO NPs were â¼70-200Â nm in size and the CS-PEO nanofibers were very uniform and free of any beads which had average diameters within the range of â¼20-130Â nm. For all of the nanofibrous mats, the water uptakes were the highest in acidic medium but they were decreased in the buffer and the least swellings were obtained in the alkaline environment. The drug incorporated mat preserved its bactericidal activity even after it was utilized in the release experiment for 8Â days in the PBS buffer. The hydrocortisone release was increased to 82% within first 12Â h while the release rate of imipenem/cilastatin was very much slower so that 20% of the drug was released during this period of time suggesting this nanofibrous mat is very suitable to inhibit inflammation (by hydrocortisone) and infection (using imipenem/cilastatin antibiotic and ZnO NPs) principally for the wound dressing purposes.
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