Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6483495 | Acta Biomaterialia | 2015 | 11 Pages |
Abstract
Treatment options for triple-negative breast cancer (TNBC) are limited, as patients do not respond to endocrine or targeted therapies, making this a difficult disease to treat. Multifunctional Chit-Au NRs were fabricated using a layer-by-layer assembly approach for delivery of siRNA gene silencing agents and thermal therapy to TNBC cells. This platform successfully suppressed oncogene expression in vitro and in vivo, resulting in anticancer activity, which was further enhanced through NIR irradiation.286
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Authors
Zhizhou Yang, Tengfei Liu, Yan Xie, Zhaorui Sun, Hongmei Liu, Jinfeng Lin, Changjing Liu, Zong-Wan Mao, Shinan Nie,