Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6483939 | Biochemical Engineering Journal | 2016 | 33 Pages |
Abstract
The increase of initial kLa from 7Â hâ1 to 55Â hâ1 led to 7.8-fold increase of citric acid final concentration. Experiments were also performed at controlled dissolved oxygen (DO) and citric acid concentration increased with DO up to 60% of saturation. Thus, due to the simpler operation setting an optimal kLa than at controlled DO, it can be concluded that kLa is an adequate parameter for the optimization of citric acid production from crude glycerol by Y. lipolytica and to be considered in bioprocess scale-up. Our empirical correlation, considering the operating conditions and cellular density, will be a valid tool for this purpose.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
PatrÃcia Ferreira, Marlene Lopes, Manuel Mota, Isabel Belo,