“Stepwise Extraction” strategy-based injectable bioresponsive composite implant for cancer theranostics

A novel “stepwise extraction” strategy has been proposed and demonstrated in constructing injectable bioresponsive composite implant, which features unique theranostic responsivenesses to exogenous and external triggers. The as-designed implant exhibits theranostic functions and biodegradability for cancer treatment based on the change of intratumoral microenvironment and the needs of therapeutic process, which has been systematically demonstrated both in vitro and in vivo.299