Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6484827 | Biomaterials | 2016 | 32 Pages |
Abstract
Near infrared-absorbing hydrogels are used for the repeated photothermal treatments of cancer. However, a long-term retention of hydrogel in the body leads to increased risk of toxicity. Here we developed an injectable and on-demand degradable hydrogel to conduct the repeated photothermal therapies (PTTs). Alginate-calcium hydrogel immobilized dendrimer-encapsulated platinum nanoparticles (DEPts) in its matrix represented excellent biocompatibility, and was degraded upon injecting chelates. Results from the in vivo studies reveal that the hydrogel/DEPts-mediated repeated PTTs suppressed tumor growth efficiently, and the hydrogel was degraded on-demand to allow renal secretion of DEPts out of the body. Furthermore, coating hydrogel/DEPts on the tumor instead of intratumoral injection could still ablate tumor efficiently. Our investigation provides a smart and safe hydrogel for photothermal cancer therapy.
Related Topics
Physical Sciences and Engineering
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Bioengineering
Authors
Changping Wang, Xinyu Wang, Kunyu Dong, Jian Luo, Qiang Zhang, Yiyun Cheng,