Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6484882 | Biomaterials | 2016 | 28 Pages |
Abstract
A novel phototheranostic platform based on tri-malonate derivative of fullerene C70 (TFC70)/photosensitizer (Chlorin e6, Ce6) nanovesicles (FCNVs) has been developed for effective tumor imaging and treatment. The FCNVs were prepared from amphiphilic TFC70-oligo ethylene glycol -Ce6 molecules. The developed FCNVs possessed the following advantages: (i) high loading efficiency of Ce6 (up to â¼57 wt%); (ii) efficient absorption in near-infrared light region; (iii) enhanced cellular uptake efficiency of Ce6 in vitro and in vivo; (iv) good biocompatibility and total clearance out from the body. These unique properties suggest that the as-prepared FCNVs could be applied as an ideal theranostic agent for simultaneous imaging and photodynamic therapy of tumor. This finding may provide a good solution to highly efficient phototheranostic applications based on fullerene derivatives fabricated nanostructures.
Keywords
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Mirong Guan, Jiechao Ge, Jingyi Wu, Guoqiang Zhang, Daiqin Chen, Wei Zhang, Ying Zhang, Toujun Zou, Mingming Zhen, Chunru Wang, Taiwei Chu, Xiaojuan Hao, Chunying Shu,