Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6485040 | Biomaterials | 2016 | 10 Pages |
Abstract
Neutralizing TGF-β1 within PRP significantly promotes muscle regeneration while significantly reducing fibrosis. Not only did the neutralization reduce fibrosis, it enhanced angiogenesis, prolonged satellite cell activation, and recruited a greater number of M2 macrophages to the injury site which also contributed to the efficacy that the customized PRP had on muscle healing.
Related Topics
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Chemical Engineering
Bioengineering
Authors
Hongshuai Li, Justin J. Hicks, Ling Wang, Nick Oyster, Marc J. Philippon, Shepard Hurwitz, MaCalus V. Hogan, Johnny Huard,