| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6485456 | Biomaterials | 2015 | 9 Pages |
Abstract
Currently approved surgical tissue glues do not satisfy the requirements for ideal bioadhesives due to limited adhesion in wet conditions and severe cytotoxicity. Herein, we report a new light-activated, mussel protein-based bioadhesive (LAMBA) inspired by mussel adhesion and insect dityrosine crosslinking chemistry. LAMBA exhibited substantially stronger bulk wet tissue adhesion than commercially available fibrin glue and good biocompatibility in both in vitro and in vivo studies. Besides, the easily tunable, light-activated crosslinking enabled an effective on-demand wound closure and facilitated wound healing. Based on these outstanding properties, LAMBA holds great potential as an ideal surgical tissue glue for diverse medical applications, including sutureless wound closures of skin and internal organs.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Eun Young Jeon, Byeong Hee Hwang, Yun Jung Yang, Bum Jin Kim, Bong-Hyuk Choi, Gyu Yong Jung, Hyung Joon Cha,