Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6486311 | Biomaterials | 2015 | 8 Pages |
Abstract
Spinal cord injury (SCI) is still a worldwide clinical challenge for which there is no viable therapeutic method. We focused on developing combinatorial methods targeting the complex pathological process of SCI. In this study, we implanted linear-ordered collagen scaffold (LOCS) fibers with collagen binding brain-derived neurotrophic factor (BDNF) by tagging a collagen-binding domain (CBD) (LOCSÂ +Â CBD-BDNF) in completely transected canine SCI with multisystem rehabilitation to validate its potential therapeutic effect through a long-term (38 weeks) observation. We found that LOCSÂ +Â CBD-BDNF implants strikingly promoted locomotion and functional sensory recovery, with some dogs standing unassisted and transiently moving. Further histological analysis showed that administration of LOCSÂ +Â CBD-BDNF reduced lesion volume, decreased collagen deposits, promoted axon regeneration and improved myelination, leading to functional recovery. Collectively, LOCSÂ +Â CBD-BDNF showed striking therapeutic effect on completely transected canine SCI model and it is the first time to report such breakthrough in the war with SCI. Undoubtedly, it is a potentially promising therapeutic method for SCI paralysis or other movement disorders caused by neurological diseases in the future.
Related Topics
Physical Sciences and Engineering
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Authors
Sufang Han, Bin Wang, Wei Jin, Zhifeng Xiao, Xing Li, Wenyong Ding, Meghan Kapur, Bing Chen, Baoyu Yuan, Tiansheng Zhu, Handong Wang, Jing Wang, Qun Dong, Weibang Liang, Jianwu Dai,