Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6486486 | Biomaterials | 2015 | 11 Pages |
Abstract
Developing novel multifunctional nanoparticles (NPs) with robust preparation, low cost, high stability, and flexible functionalizability is highly desirable. This study provides an innovative platform, termed unibody core-shell (UCS), for this purpose. UCS is comprised of two covalent-bonded polymers differed only by the functional groups at the core and the shell. By conjugating Gd3+ at the stable core and encapsulating doxorubicin (Dox) at the shell in a pH-sensitive manner, we developed a theranostic NPs (UCS-Gd-Dox) that achieved a selective drug release (75% difference between pH 7.4 and 5.5) and MR imaging (r1Â =Â 0.9 and 14.5Â mmâ1Â sâ1 at pH 7.4 and 5.5, respectively). The anti-cancer effect of UCS-Gd-Dox is significantly better than free Dox in tumor-bearing mouse models, presumably due to enhanced permeability and retention effect and pH-triggered release. To the best of our knowledge, this is the simplest approach to obtain the theranostic NPs with Gd-conjugation and Dox doping.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Lin-Chen Ho, Chao-Hsiung Hsu, Chung-Mao Ou, Chia-Wei Wang, Tsang-Pai Liu, Lian-Pin Hwang, Yung-Ya Lin, Huan-Tsung Chang,