Natural products as modulators of the nuclear receptors and metabolic sensors LXR, FXR and RXR

Article ID	Journal	Published Year	Pages	File Type
6486531	Biotechnology Advances	2018	78 Pages	PDF

Abstract

This review aims to briefly summarize current basic knowledge regarding the liver X (LXR) and farnesoid X receptors (FXR) that form permissive heterodimers with retinoid X receptors (RXR). Natural product-based ligands for these receptors are summarized and the potential of LXR, FXR and RXR as targets in precision medicine is discussed.

Keywords

ABC AMPK CREB DCA NF-κB ACC IL-6 SREBP-1c ROR HTS CETP DBD LBD CyP CAT ICP SUMO HDL HMGR FAS EGCG BGP ITC COX-2 FGF SHP IBD iNOS ALT LDLR Epigallocatechin-3-gallate Cpt1a PPAR CD36 Nurr1 AP-1 TLR AP2 Heme oxygenase-1 PEPCK GLUT4 PUFAs Retinoid X receptor RCT CDCA MDR3 BSEP PBC SOAE FXR HSP27 VDR LPL SR-BI VLDL LXR RAR RXR Ntcp HMOX-1 G6Pase PXR FGFR4 HNF4α 6-ECDCA OATP stearoyl-CoA desaturase-1 LRH-1 FCHL ETB NPC1L1 PLTP SR-A NUR77 BACS TRPV6 SCD-1 Q3GA HPLC-ESI-MS FABP3 scavenger receptor class A acyl-CoA carboxylase ELOVL6 UGT2B4 Rhus verniciflua stokes TR-FRET WBM Riccardin C SULT2A1 calbindin D9k CRBPII NAFLD IBABP BAAT OSTα/β RAR-related orphan receptor quercetin-3-O-glucuronide sulfotransferase 2A1 nuclear magnetic resonance AMP-activated protein kinase ERK1/2 farnesoid X receptor HMG-CoA reductase JNK1/2 RVs Asbt alanine transaminase apo apolipoprotein LCA amyotrophic lateral sclerosis Chenodeoxycholic acid Deoxycholic acid Arachidonic acid Oleic acid docosahexaenoic acid Lithocholic acid Polyunsaturated fatty acids fatty acid synthase Cholic acid Time-resolved fluorescence resonance energy transfer apical sodium-dependent bile acid transporter interleukin 6 Alzheimer's disease ALS Nonalcoholic fatty liver disease Inflammatory bowel disease Activation function triglyceride NMR SPR Surface plasmon resonance direct repeat inverted repeat Toll-like receptor ATP-binding cassette transporter glucose transporter 4 TICE DNA-Binding Domain ligand-binding domain DHA Retinoic acid circular dichroism World Health Organization inducible nitric oxide synthase Metabolic syndrome Cytochrome P450 Primary biliary cirrhosis cyclooxygenase 2 small heterodimer partner response element high-throughput screening fibroblast growth factor nuclear factor κB Natural products phosphoenolpyruvate carboxykinase White button mushroom Lipoprotein lipase high density lipoprotein very low density lipoprotein low density lipoprotein LDL CAR Multiple sclerosis familial combined hyperlipidemia fatty acid binding protein 3 Phospholipid transfer protein cholesteryl ester transfer protein Heat shock protein 27 activator protein 1 angiopoietin-like protein 4 Sterol regulatory element binding protein-1c Multidrug resistance protein 3 cAMP response element-binding protein extracellular signal-regulated protein kinase 1/2 Brazilian green propolis Precision medicine sodium taurocholate cotransporting polypeptide Organic anion transporting polypeptide Single nucleotide polymorphism Bile salt export pump SNP carnitine palmitoyltransferase 1a Isothermal titration calorimetry liver X receptor chloramphenicol acetyltransferase Intrahepatic cholestasis of pregnancy reverse cholesterol transport WHO Ulcerative colitis small ubiquitin-like modifier LDL receptor constitutive androstane receptor Androgen Receptor Estrogen receptor Retinoic acid receptor fibroblast growth factor receptor 4 peroxisome proliferator-activated receptor Mineralocorticoid receptor thyroid hormone receptor Vitamin D receptor Progesterone receptor Pregnane X receptor liver receptor homolog-1 glucocorticoid receptor scavenger receptor class B type I Nuclear receptor nuclear receptors