Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6486541 | Biotechnology Advances | 2018 | 50 Pages |
Abstract
In the present paper, we will discuss on the importance of autophagy in the central nervous system, and outline the relation between autophagic pathways and the pathogenesis of neurodegenerative disorders. The potential therapeutic benefits of naturally occurring phytochemicals as pharmacological modulators of autophagy will also be addressed. Our findings provide renewed insight on the molecular modes of protection by polyphenols, which is likely to be at least in part mediated not only by their potent antioxidant and anti-inflammatory effects, but also through modulation of autophagic processes to remove the aberrant protein aggregates.
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Authors
Seyed Fazel Nabavi, Antoni Sureda, Ahmad Reza Dehpour, Samira Shirooie, Ana Sanches Silva, Kasi Pandima Devi, Touqeer Ahmed, Nafeesa Ishaq, Rabia Hashim, Eduardo Sobarzo-Sánchez, Maria Daglia, Nady Braidy, Mariateresa Volpicella, Rosa Anna Vacca,