Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6486688 | Biotechnology Advances | 2018 | 30 Pages |
Abstract
A rapidly growing body of experimental evidence has begun to shed light on the wide ranging molecular mechanisms which modulate intra- and inter-cellular communications. A substantial quantity of the available knowledge has only been uncovered in recent years, and we are learning that donor cells release nanovesicles, known as exosomes, which regulate the cellular behavior of recipient cells following uptake. Based on the impressive capacity of exosomes in delivering their “payload”, different therapeutic agents, are currently being tested using this delivery method for more effective therapy. This review summarizes the most recent developments in exosome bioactivities and discusses the biochemical nature of exosomes and their biogenesis. It also summarizes the use of exosomes as delivery vehicles for drugs and natural compounds to the targeted site.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Ammad Ahmad Farooqi, Nishil N. Desai, Muhammad Zahid Qureshi, Daniele Rubert Nogueira Librelotto, Maria Luisa Gasparri, Anupam Bishayee, Seyed Mohammad Nabavi, Valeria Curti, Maria Daglia,