Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6487139 | Computational Biology and Chemistry | 2013 | 8 Pages |
Abstract
- We study the structural basis of APPL and Reptin binding in context with APPL1/APPL2 dimerization.
- We perform a detailed in silico analysis using the knowledge of APPL1/2 heterodimerization and infer that binding of APPLPH to BAR domain and Reptin is mutually exclusive which may facilitate Reptin in nucleocytoplasmic shuttling.
- We report new insights into the distinctive characterization of APPL-β-catenin-Reptin-HDACs ternary complex in terms of target gene regulation and transcriptional mechanisms.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
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Authors
Sajid Rashid, Zahida Parveen, Saba Ferdous, Nousheen Bibi,