Article ID Journal Published Year Pages File Type
6487162 Computational Biology and Chemistry 2013 11 Pages PDF
Abstract

- PDB-wide analysis of sequence repeats in a non-redundant set of proteins.
- Use of different bioinformatics tools such as RADAR, PDBeFOLD, PDBsum and Pfam to identify and characterize the sequence repeats in a protein.
- Sequence identity of the repeats falls in the range of 20-40% and, their superimposed structures of the sequence repeats maintain similar overall folding.
- Sequence repeats are involved in the function of the protein through functionally important residues in the repeat regions.
- Sequence repeats in the domains of the proteins show that repeats involved in the function of protein possess conserved sequence motifs.
Related Topics
Physical Sciences and Engineering Chemical Engineering Bioengineering
Authors
, ,