| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6487163 | Computational Biology and Chemistry | 2013 | 14 Pages |
Abstract
- SCB related virtual screening and docking studies can provide mechanistic insight on inhibition.
- Unlike glyoxlate response, inhibitor impact on malate seems microenvironment dependent.
- For similar microenvironments, ICL versus MS inhibition is metabolically more consequential.
- Strong ICL inhibition causes metabolite levels in persistent Mtb toward levels in non-viable Mtb.
- SCB points to a complex interplay between network structure, kinetics, and therapeutic outcome.
Keywords
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Elebeoba E. May, Andrei Leitão, Alexander Tropsha, Tudor I. Oprea,