| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6487448 | Current Opinion in Biotechnology | 2016 | 8 Pages |
Abstract
- Macrophagic inflammation and fibrosis synergistically prime the microenvironment for cancer.
- Fibrosis changes ECM physicochemical properties, which alters macrophage mechanosignaling.
- Biomaterials can mimic fibrosis-associated differences in ECM physicochemical properties.
- Tissue-engineered models permit testing the role of fibrosis in macrophage functions.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Nora L Springer, Claudia Fischbach,