Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6487642 | Current Opinion in Biotechnology | 2015 | 8 Pages |
Abstract
Several modeling frameworks for describing and redirecting cellular metabolism have been developed keeping pace with the rapid development in high-throughput data generation and advances in metabolic engineering techniques. The incorporation of kinetic information within stoichiometry-only modeling techniques offers potential advantages for improved phenotype prediction and consequently more precise computational strain design. In addition to substrate level kinetic regulatory information, the integration of a number of additional layers of regulation at the transcription, translation, and post-translation levels is sought after by many research groups. However, the practical integration of these complex biological processes into a unified framework amenable to design remains an ongoing challenge.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Anupam Chowdhury, Ali Khodayari, Costas D Maranas,