Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6487696 | Current Opinion in Biotechnology | 2015 | 8 Pages |
Abstract
- Protein-protein interactions can be modulated by more than orthosteric disruption.
- Modulator categories: 'orthosteric versus allosteric' and 'disrupting versus stabilising'.
- Interfacial binders exert secondary effects.
- Non-competitive modulation is a way around low affinity molecules.
- Non-competitive modulators require tailored screening strategies.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Gerhard Fischer, Maxim Rossmann, Marko Hyvönen,