| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6487746 | Current Opinion in Biotechnology | 2015 | 9 Pages |
Abstract
Activatable nanoprobes bring unique features for probing disease-relevant biomolecules. Inorganic nanoparticles can serve as universal quenchers for simultaneous detection of multiple biomolecules (1). Switchable signals from the inorganic nanoparticle itself can also serve as an indicator for the presence and activities of biomolecules of interest (2). Self-assembly of activatable molecular probes (3) or always-ON probes (4) can improve their chemical and structural stability, and also offer an additional activation mechanism. The use of additional nanoparticles as carriers could improve the accumulation of molecular probe in target tissues (5).
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Pengcheng Zhang, Andrew G Cheetham, Lye Lin Lock, Yaping Li, Honggang Cui,