| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6487873 | Current Opinion in Biotechnology | 2014 | 8 Pages |
Abstract
- Cell viability and time of harvest impacts greatly on the subsequent HCP profile.
- Primary and secondary clarification decisions impact on the HCP profile.
- HCPs in protein A chromatography eluates appear to predominately depend on HCP-product interactions due to co-elution of HCPs with the product.
- The degree of resin-HCP interaction depends on the matrix utilised.
- Different subsets of HCPs may interact with different mAbs.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Catherine EM Hogwood, Daniel G Bracewell, C Mark Smales,