| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6487877 | Current Opinion in Biotechnology | 2014 | 7 Pages |
Abstract
- Mammalian cell-produced therapeutic glycoproteins are heterogeneous in nature.
- Causes of product heterogeneity are highlighted.
- Examples of protein degradation by non-enzymatic and enzymatic pathways are reviewed.
- Strategies used for controlling protein degradation are described.
- Possible development of host cell lines with minimal degradative properties is discussed.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Haimanti Dorai, Subinay Ganguly,