| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6487897 | Current Opinion in Biotechnology | 2014 | 9 Pages |
Abstract
- trans-acting repressors enable synthetic regulation of target genes.
- The DNA binding domain of a TALE can be targeted to promoters to inhibit transcription.
- Non-cleaving Cas9 can be guided to target DNA by small RNAs to repress transcription.
- Synthetic sRNAs can inhibit translation and decrease message stability by binding mRNAs.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Matthew F Copeland, Mark C Politz, Brian F Pfleger,