| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6490665 | Journal of Biotechnology | 2016 | 13 Pages |
Abstract
The presented HTS procedure allowed for a fast development of an efficient production process of VLPs in E. coli. Under optimized cultivation conditions, the VP1 product totalled up to 43% of the total soluble protein fraction, yielding 1.63Â mg VP1 per mL of applied cultivation medium. The developed production process strongly promotes the murine polyoma-VLP platform, moving towards an industrially feasible technology for new chimeric vaccines.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Christopher Ladd Effio, Pascal Baumann, Claudia Weigel, Philipp Vormittag, Anton Middelberg, Jürgen Hubbuch,