Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6491125 | Journal of Biotechnology | 2015 | 12 Pages |
Abstract
- One-tissue format enables multiple tissue combinations on chip without design changes.
- Tilting-based perfusion eliminates any tubing and ensures device robustness.
- Perfusion leads to improved liver function on chip.
- On-chip activation of the pro-drug cyclophosphamide leads to reduced tumor growth.
- Chip design allows for biochemical and optical assays to assess drug response.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Jin-Young Kim, David A. Fluri, Rosemarie Marchan, Kurt Boonen, Soumyaranjan Mohanty, Prateek Singh, Seddik Hammad, Bart Landuyt, Jan G. Hengstler, Jens M. Kelm, Andreas Hierlemann, Olivier Frey,