| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6491284 | Journal of Biotechnology | 2014 | 7 Pages |
Abstract
The pyruvate dehydrogenase complex (PDHC) catalyzes the oxidative thiamine pyrophosphate-dependent decarboxylation of pyruvate to acetyl-CoA and CO2. Since pyruvate is a key metabolite of the central metabolism and also the precursor for several relevant biotechnological products, metabolic engineering of this multienzyme complex is a promising strategy to improve microbial production processes. This review summarizes the current knowledge and achievements on metabolic engineering approaches to tailor the PDHC of Corynebacterium glutamicum for the bio-based production of l-valine, 2-ketosiovalerate, pyruvate, succinate and isobutanol and to improve l-lysine production.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Bernhard J. Eikmanns, Bastian Blombach,