Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6492113 | Journal of Biotechnology | 2012 | 6 Pages |
Abstract
⺠The incorrectly folded cIFN in supernatant is produced in cell. ⺠Cell secretes incorrectly folded recombinant cIFN at high specific growth rate. ⺠cIFN expression level decreases at high specific growth rate. ⺠Incorrectly folded cIFN forms aggregates intracellularly. ⺠These results suggest that the efficient heterologous expression of cIFN is limited by high cell growth.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Dan Wu, Ju Chu, Yu-You Hao, Yong-Hong Wang, Ying-Ping Zhuang, Si-Liang Zhang,