Article ID Journal Published Year Pages File Type
6494155 Metabolic Engineering 2017 8 Pages PDF
Abstract
We systematically overexpressed or deleted genes with significant transcriptional changes in CEN.PK low and high-producing strains. The knockout of some of the downregulated transporters triggered a 20-50% improvement in the synthesis of p-CA in the CEN.PK high-producing strain. This study demonstrates the importance of transporters in the engineering of cell factories for production of small molecules.
Related Topics
Physical Sciences and Engineering Chemical Engineering Bioengineering
Authors
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