Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6494155 | Metabolic Engineering | 2017 | 8 Pages |
Abstract
We systematically overexpressed or deleted genes with significant transcriptional changes in CEN.PK low and high-producing strains. The knockout of some of the downregulated transporters triggered a 20-50% improvement in the synthesis of p-CA in the CEN.PK high-producing strain. This study demonstrates the importance of transporters in the engineering of cell factories for production of small molecules.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Angelica Rodriguez, Yun Chen, Sakda Khoomrung, Emre Ãzdemir, Irina Borodina, Jens Nielsen,